I've done it a few times with a normie party as bst, alot of fun.
In Nyzule you need spike dmg mainly, in order to feed the mobs less TP over time and kill fast to complete the floors before the timer expires.
That being said we bsts falter abit on that point, however farming the lower floors could be fun but getting 1-5 completed would be quite a challenge I would think.
Now a bst & smn party might be interesting
I could be wrong that's just my take with my limited experience in Nyzule Isle.